Sprague-Dawley and Wistar are the main rat strains. Why Are Rats The Most Preferred Animals For Experiments? A number of laboratory tests performed on rats involve the safety of chemicals, whether used in medicines, food products or cosmetics. Experimental animal models of hypertension and atherosclerosis have become a valuable tool for providing information on etiology, pathophysiology, and complications of the disease and on the efficacy and mechanism of action of various drugs and compounds used in … A summary and overview of the mice and rats used in biomedical research, based on a survey of formal publications. ... Why Are Rats The Most Preferred Animals For Experiments? In summary, the creation and maintenance of the Wistar Rats as standardized animals can be attributed to the breeding work of Helen Dean King, coupled with the management and husbandry methods of Milton Greenman and Louise Duhring, and with supporting documentation provided by Henry Donaldson. As a model of human disease, the rat offers many advantages over the mouse and other organisms. I'm not really sure, but the wistar strain is the most well established, so there's not much reason to change it. In this instalment, we look at the original lab rats: Rattus norvegicus. The Wistar rat, Wistar Hannover (Wistar HAN) rat, and Wistar Unilever rat are outbred rat strains, while the Wistar Kyoto and Wistar Furth rats are inbred strains. You would have seen and read a lot of reports and experiments where rats are used to test drugs or treatments. Rat. Several suppliers breed and sell Wistar rats worldwide, including Harlan Laboratories (Ha; Horst, The Netherlands) and Charles River GmbH (CR; Sulzfeld, Germany). Like other rat breeds used in research, the Sprague Dawley makes for a good general model for the study of human toxicology, reproduction, pharmacology, and behavioral research. Life's Little Mysteries explains what makes these rodents the … The life expectancy of the world population has increased due to several factors, such as developments in … • Used in virtually all disciplines of biomedical research including toxicology and pharmacology • Excellent reproductive performance makes theSD rat a good model for generating timed pregnant females • Origin:TheSprague Dawley outbred model was developed bySprague Dawley, Inc. NIH received stock fromSprague Dawley, Inc in 1945.The rats are Mice and rats make up 95 percent of all animals used in medical research, from drug development to testing dietary supplements. The widespread use of the Wistar Rats, however, is a function of the ingenuity of Milton Greenman … A summary and overview of the mice and rats used in biomedical research, based on a survey of formal publications. In summary, the creation and maintenance of the Wistar Rats as standardized animals can be attributed to the breeding work of Helen Dean King, coupled with the management and husbandry methods of Milton Greenman and Louise Duhring, and with supporting documentation provided by Henry Donaldson. I have found that in vivo testing of anti diabetic drugs are mostly done on male wistar rats. Most of the times we hate them, sometimes we adopt them, but there are as well many other instances when rats are used by researchers, with medical testing purposes in mind. The Sprague Dawley breed of rat, like those used in the current Psychology 381 class, is used widely throughout medical and psychological research. The Wistar rat is one the most commonly used outbred strains in cardiovascular research (Berardi et al., 2011, van Dijk et al., 2011). Carefully bred rats with documented genetic histories are used in animal testing for a number of reasons, including their frequent reproduction, genetic purity and similarities to human biology. The outbred Wistar and Wistar HAN strains have been used widely in Europe for preclinical safety assessments, including two … I am a research scholar , conducting research on antidiabetic potential of herbal compounds. 1. Material and Methods Experimental animals Six strains of Rattus norvegicus com-monly used in the laboratory were investi-gated: Wistar, Wistar Munich, Brown Nor-